Macromolecularab initiophasing enforcing secondary and tertiary structure
نویسندگان
چکیده
منابع مشابه
Macromolecular ab initio phasing enforcing secondary and tertiary structure
Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main barriers: structure size and resolution of the data. Current approaches to extend the scope of ab initio phasing include use of the Patterson function, density modification a...
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Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling, fold generation and de novo methods developed ...
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Four levels in protein structural organization are commonly identified. Primary structure is a sequence of amino acids. Secondary structure is represented by regular local conformations of polypeptide chain, such as α-helix or β-strand. The combinations of two secondary structure elements are also sometimes referred to as secondary (or supersecondary) structure. The example is a β-hairpin forme...
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Is highly approximate knowledge of a protein's backbone structure sufficient to successfully identify its family, superfamily, and tertiary fold? To explore this question, backbone dihedral angles were extracted from the known three-dimensional structure of 2,439 proteins and mapped into 36 labeled, 60 degrees x 60 degrees bins, called mesostates. Using this coarse-grained mapping, protein conf...
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The recent interest in function of various RNA structures, reflected in the growth of solved RNA structures in PDB, calls for methods for effective and efficient similarity search in RNA structural databases. Here, we propose a method called SETTER (RNA SEcondary sTructurebased TERtiary structure similarity) based on partitioning of RNA structures into so-called generalized secondary structure ...
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ژورنال
عنوان ژورنال: IUCrJ
سال: 2015
ISSN: 2052-2525
DOI: 10.1107/s2052252514024117